Causes of Hormone Replacement Therapy (HRT) | Oncology

Hormone replacement therapy (HRT)

What do you need to know about Hormone replacement therapy (HRT)?

Hormone replacement therapy (HRT) can help balance estrogen and progesterone levels during or near menopause. There are also many other reasons why a doctor may prescribe supplemental sex hormones.

Hormone replacement therapy also known as menopausal hormone therapy, HRT helps eliminate sweating, hot flashes, and other symptoms of menopause. It also reduces the risk of osteoporosis. Some types of HRT contain progesterone and estrogen, while others contain only estrogen. Sometimes they contain testosterone.

Next, learn about the uses, types, and risks of HRT.

Uses of hormone replacement therapy

Hormone replacement therapy can help solve many problems. The dosage of hormones depends on the reason for prescribing this type of treatment.


Menopause is not a disease. It is a natural transition of the years that a girl can reproduce to the next stage of life.

Most people go through menopause without the need for any treatment. However, if the transition causes distressing or distracting symptoms, there are a variety of therapies available.

Around menopause, most people experience:

  • Hot lights and night sweats
  • Vaginal dryness
  • Osteoporosis
  • Urinary problems
  • Hair is thinning
  • Trouble sleeping
  • Humor changes
  • Irregular periods
  • Concentration and memory difficulties.

Hormone replacement therapy (HRT) can help maintain some of the features mentioned above.

Also, some studies have suggested that Hormone replacement therapy (HRT) can help:

  • Improve muscle function
  • Reduce the risk of heart failure and stroke.
  • Reduce mortality in men who have left menopause.
  • In some, when used with caution, it prevents aging of the skin.

However, more research is needed to confirm these uses.

Other uses of hormone replacement therapy

A doctor can also prescribe different types and combinations of sex hormones:

  • Natality control
  • Low levels of testosterone in the blood
  • The transition of the sex assigned at birth
  • Prostate cancer

Hormones and menopause

Progesterone and estrogen levels contribute to the menstrual cycle each month, in women. These levels vary throughout a person’s life.


  • Most women have low levels of estrogen and progesterone by the age of 40, but the menstrual cycle continues for some time.
  • Periods may become less regular, and during this time hot flashes and other menopausal symptoms may begin to appear.
  • However, as Stru menstruation continues, the chances of getting pregnant decrease over time.
  • Perimenopause, or menopause, typically lasts up to 7 years but can last up to 14 years, according to the National Institutes on Aging.


Menopause begins 12 months after a person’s last period. On average, it occurs in 52-year-olds in the United States. After menopause, it is no longer possible to get pregnant without medical help.

Everyone experiences menopause differently, but hot flashes, mood swings, and other symptoms are common. A study published in 2015 found that in more than half of women, vasomotor symptoms, such as hot flashes:

  • Lasts more than 7 years
  • Start before the last monthly period
  • Continue for an average of 4.5 years after the end of menstruation

During this time, HRT helps maintain symptoms.

Early menopause

For some, menopause begins early and HRT can help if this happens.

People who initially experience the transition:

  • Surgery was done to remove the uterus, ovaries, or both
  • Is there some kind of cancer
  • Some contain genetic or chromosomal factors
  • There are some autoimmune diseases.
  • Smoke

Sometimes the transition begins for no apparent reason.

Anyone who has had surgery or is undergoing other treatment that affects their reproductive system should ask about the possibility of experiencing early menopause. If a person needs it, the doctor can explain the range of treatments available.

Side effects

Hormone replacement therapy (HRT) helps control hot flashes and other symptoms of menopause, which can also cause adverse effects.

Depending on the type of treatment, may include:

  • Acne
  • Swelling
  • Indigestion
  • Tender breasts
  • Swelling of the breasts or other parts of the body
  • Abdominal or back pain
  • Leg cramps
  • Headache
  • Migraine
  • Nausea
  • Vaginal bleeding
  • Humor changes
  • Disappointment

These side effects go away after a few weeks.

It is important to inform your doctor about any side effects that may cause you concern. They can adjust the dose or suggest an alternative.

Is hormone replacement therapy safe?

In the past, it was common to use hormone therapy during menopause, but Hormone replacement therapy (HRT) may not be safe or appropriate for all people, especially those with specific risk factors.

Now, many doctors agree that it is safe to take hormone therapy:

  • For moderate to severe hot flashes and vaginal dryness
  • Up to 59 years
  • Within 10 years of menopause
  • In the lowest possible dose, for the shortest possible time.

However, the general health and preferences of the individual should influence the decision.

Can hormone replacement therapy (HRT) cause cancer?

Some previous research has linked HRT to endometrial, breast, and ovarian cancer. However, this research did not examine all aspects of HRT. The American Cancer Society believes that this risk depends on the type of treatment and the type of cancer.

They report that one type of HRT slightly increases the risk of breast cancer, while another type reduces the risk. Anyone considering using HRT should discuss the specific benefits and risks with their doctor.

Does it cause weight gain?

Some people are concerned that hormone therapy could lead to weight gain, but there is no evidence to support this.

Eating a healthy diet and getting plenty of exercises can help maintain the weight gain that normally affects middle-aged men and women alike.

Types of hormone replacement therapy (HRT)

There are different ways to provide hormone therapy, and different types offer different combinations and amounts of hormones.

Common types:

  • Estrogen-only HRT: A doctor may prescribe this if a person’s uterus and ovaries have been removed, in which case progesterone is not needed.
  • Serial or cyclical HRT: It is a good option if premenopausal symptoms appear; The dose can be aligned with the cycle of the structure.
  • Persistent HRT: After menopause, a doctor may prescribe a continuous combination of estrogen and progesterone.
  • Topical estrogen: Vaginal tablets, creams, or rings can help with urogenital symptoms, including vaginal dryness and irritation.

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